This week, we’re bringing back a classic episode that originally aired in November of 2020, featuring Dr. Ira Kirschenbaum, “the Godfather of Orthopedics”.
Remember the early 90’s orthopedic website, www.bonehome.com? Did you know Dr. Kirschenbaum coded and built the website? Outside of his nickname as The Godfather of Orthopedics, Dr. Sigman has also dubbed him the “Creator of Orthopedics on the Internet.” It’s an information packed episode on:
-BronxCare’s mission of high quality and cost reduction of medical care
-Partnership in Swiftpath.com: Episode of care management company with digital patient engagement tools. Improving outcomes for patients with an opioid sparing approach, reducing complications, digital PT and monitoring of the patient post-joint replacement
–Mykneeyourknee.com: Chronicling knee replacement surgery on a knee replacement surgeon
In this episode, Scott sits down with Dr. Rick Angelo, a retired private practice orthopedic surgeon and sports medicine specialist out in Seattle, Washington. Here, they discuss the breadth of his career, the incredible mentors he was able to work under, his legacy in professional education, his involvement in the Arthroscopy Association of North America, his passion for AI in the orthopedic space, and more.
In this episode, Scott chats with Dr. Raffy Mirzayan, an orthopedic surgeon and sports medicine specialist in southern California. They discuss the path that led him to where he is today, including his time living in multiple other countries and learning five different languages, English being his fifth. They also cover his involvement with the Shoulder 360 course being held in April in South Beach Miami.
In this episode, Dr. Sigman sits down with Michael Kroin, CEO and Managing Partner at Physician Growth Partners in Chicago, Illinois. Here, Michael discusses the role Physician Growth Partners plays in private equity deals, how you can find the perfect firm to work with, his career in healthcare private equity, and more.
This episode features Dr. Marc Labbé, an orthopedic surgeon and sports medicine specialist in Houston, Texas. In this episode, he and Dr. Sigman talk about a new project he’s been working on, the pathway to starting and financing a new company, his education background and career development over the years, and more.
In this episode, Dr. Sigman sits down with Dr. Grant Garrigues, an Associate Professor and shoulder and elbow surgeon at Midwest Orthopedics at Rush, and the team physician for both the Chicago Bulls and Chicago White Sox. Here, they discuss his education background, which includes both Harvard Medical School and MIT’s Health Science Technology Program, his time in Siberia completing a fellowship, his experience taking care of the Bulls and White Sox, and more.
Dr. Gerhardt is a board certified orthopaedic surgeon who joined Santa Monica Orthopaedic and Sports Medicine Group in 2002. He specializes in sports medicine, which includes arthroscopic surgery of the hip, knee, ankle and shoulder. Dr. Gerhardt has also completed sub-specialty training in hip arthroscopy, and is considered one of the leading physicians in the country in this arena. He has extensive experience in cutting edge, minimally invasive techniques for treating a wide spectrum of hip injuries.
Topics include:
-The influence of his father, who was an engineer, and tinkering with tools to guide him into the path of becoming an orthopedic surgeon.
-Dr. Gerhardt grew up in California and earned his undergraduate degree from UC San Diego. He attended medical school at the Medical College of Pennsylvania and then completed his orthopedic surgical residency at the University of Southern California where he served as Chief Resident of his class. He then began a Sports Medicine Fellowship at Santa Monica Orthopaedic and Sports Medicine Group. After fellowship he sought further training in hip arthroscopy with Dr. Thomas Byrd at the Nashville Sports Medicine and Orthopaedic Clinic. Upon completion of his training he joined the Santa Monica and Sports Medicine Group and has remained there since.
-We hear from Dr. Gerhardt about what’s new and exciting upcoming in hip arthroscopy.
-Dr. Gerhardt discusses his passion as the head team physician LA Galaxy and Federation for Men’s U.S. Soccer. He also talks about how he was the physician for the TV show Dancing with the Stars. There’s a reason his website is losangelessportssurgeon.com.
Dr. Jacob Kirsch is an orthopedic surgeon specializing in shoulder and elbow and is an attending physician at New England Baptist Hospital. He is particularly interested in complex problems of the shoulder requiring shoulder replacement, sports related injuries, shoulder instability with bone loss, irreparable tendon tears and failed previous surgery. Dr. Kirsch is going into his third year in practice and already has 54 publications and 14 book chapters.
Topics include:
-Dr. Kirsch completed his orthopaedic surgery residency at the University of Michigan, where he was awarded a resident teaching award for his dedication to educating his peers. While at Michigan, he also served as a team physician for the University of Michigan Men’s Basketball team for several years. He’s a Wolverine now proudly wearing Michigan sports gear.
-Dr. Kirsch also received advanced international training in shoulder surgery from world-renowned experts in Lyon, France. Dr. Kirsch then completed a fellowship in shoulder and elbow reconstruction at the Rothman Institute in Philadelphia, Pennsylvania.
-He gives advice for orthopedic surgeons going into practice and what’s important to look for as you’re starting your career. Dr. Kirsch also discusses the importance of social media, networking, building your brand and joining societies and committees to be successful in your practice.
-Dr. Kirsch also discusses the importance of evidence-based medicine, as seen in his massive number of publications in his short career.
Jamie Rindler is the Founder & CEO of Marvel Group. He helps private practice Spine Surgeons attract more ideal patients and referral sources through their exclusive surgical outcome patient warranty.
Marvel Group was founded in 2015 with a simple mission: to protect and empower patients, surgeons, and team members by providing resources that improve spine surgery. They do this to serve patients, not the system. They have grown into one of the most talked-about value added spine device companies in the country, thanks to their innovative programs, products and dedication to customer service.
Topics include:
-Jamie grew up in Dayton, OH and is a graduate of The Ohio State University. He discusses the importance of family, having 6 kids, and the family influence in launching the Marvel Group. He discusses how he came up with the idea of Marvel Group after a personal back surgery experience with financial risk.
-We hear about Marvel Group’s unique marketing initiatives with a surgical outcome patient warranty and how Jamie developed this novel idea in the orthopedic industry. He details how he originally started an insurance company to help bring into the fold of Marvel Group to help support initiatives.
-Marvel Group’s Surgical Stewardship program incentivizes surgeons, treatment facilities, insurance companies and medical device manufacturers to align themselves around producing the best possible outcome for the patient. It’s made possible by providing the patient a refund if a re-operation is needed called the Patient Promise.
-Independent spine surgeons and their facilities have found that patients will seek out the surgeon who offers the Patient Promise because it’s reassuring to know that the surgical team stands behind their work with a money back guarantee. By partnering with Marvel Group, surgeons can focus more on providing high quality patient care and less about growing their businesses.
This episode is brought to you by Koha Health. At Koha Health, their goal is empowering your practice to achieve total financial health.
We have on one of the great leaders in orthopedics for this episode who trained some of the best “who’s who” sports medicine fellows. Dr. Russell Warren joined the Hospital for Special Surgery on January 1, 1977 and served as surgeon-in-chief from 1993 to 2003. Dr. Warren is the also the emeritus team physician for the New York Giants football team.
Topics include:
-After receiving his medical degree from the State University of New York at Syracuse in 1966, he completed a 1-year surgical residency at St. Luke’s Hospital in New York and went on to serve as a Lt. Commander for the U.S. Navy during Vietnam. For his service, Dr. Warren received the U.S. Navy Medal of Commendation in 1969.
-He discusses the evolution of Hospital of Special Surgery during his tenure. When he started, they did about 6,000 cases per year and now up over 35,000 surgeries per year.
-Dr. Warren talks about his role as a Board Member at American Orthopedic Partners, a private equity platform.
This is a special episode with Ukrainian born and bred orthopedic surgeon, Dr. Vladyslav Kozanchuk with specialties in hip, knee and shoulder arthroplasty.
This is one of our most impactful episodes being in the trenches of war in Ukraine. It was a challenge getting Dr. Kozanchuk on for this episode in-between the blackouts and having good cell service to call in. Dr. Kozanchuk showed up to the recording with a smile on his face and immense pride for his country. He says “We won’t surrender. Russia won’t win. We will win.” He discusses the pride for all the soldiers on the front lines and support Ukraine receives globally.
Topics include:
-On our recording day, there are 267 injured soldiers in the ward with a train of another 100 wounded soldiers coming in later that night. With a curfew from 11p-5a, there are some nights Dr. Kozanchuk doesn’t make it home and needs to wait until the curfew is lifted in the morning. In addition to the wounded soldiers, there are ongoing elective surgeries within their National Health Service.
– Dr. Kozanchuk provides a shout out to Dr. Kenji Inaba from Keck Medicine and Dr. Gregory Beilman from University of Minnesota for traveling to his hospital and providing their services during the war.
Joaquin Sanchez-Sotelo, M.D., Ph.D., is a Mayo Clinic physician-scientist who has several areas of interest in orthopedic research. His research interests include surgical conditions affecting the shoulder and elbow joints, the application of artificial intelligence to shoulder and elbow surgery, and strategies in individualized medicine.
-Dr. Sanchez-Sotelo was born in Madrid, Spain. It’s in the family business with his father being an orthopedic surgeon. It was in his blood to go into orthopedics.
-We hear about his path in getting a fellowship at Mayo Clinic after Madrid. It’s our first guest who has received his acceptance for a fellowship through a telegram. He is still at the Mayo Clinic and a lifer there.
-What’s it like working at the Mayo Clinic? It’s non-profit organization run by physicians. Dr. Sanchez-Sotelo says no one really chooses to live in Rochester, Minnesota unless you love Mayo and are centered around patient care.
-Robots are finally coming to the shoulder! This is Dr. Sanchez-Sotelo’s passion and says robots will provide accuracy, precision and improve outcomes for patients.
Dr Patrick St Pierre is an orthopedic surgeon, shoulder specialist in Rancho Mirage, CA. He has an amazing 20+ year military career and is a world renowned leader in the Army.
Dr. St. Pierre is a graduate of the United States Military Academy at West Point and the Uniformed Services University of Health Sciences in Bethesda, Maryland. After completing his Orthopedic surgery residency at Madigan Army Medical Center, he completed fellowships in Medical Research at the Walter Reed Army Institute of Research and in Orthopedic Sports Medicine at West Point.
Topics include:
-Dr. St Pierre’s father was in the Air Force and traveled around in his youth. His family is originally from Dr. Sigman’s backyard in Lowell, MA and settled in Massachusetts after his father retired from the Air Force.
-He was originally drawn to cardiology due to his mother having a heart condition. After studying cadets with ankle injuries and getting experience in the military with orthopedics, it led him to a career in this specialty.
-Dr. St. Pierre is very involved in Sports Medicine and Shoulder research and has been recognized with several international and national awards. He has written numerous articles and book chapters, and has edited four books on Sports Medicine. We discuss one of his breakthrough studies in JBJS on rotator cuff repair.
-What are the innovations in shoulder arthroplasty? Dr. St. Pierre discusses he’s working with a great orthopedic surgeon team at Stryker on a robotic system for the shoulder.
This episode is brought to you by TrackableMed, the place to go to help grow your new patient base.
This episode is also brought to you by Heron Therapeutics. Please see full Prescribing Information, including Boxed Warning or visit www.ZYNRELEF.com.
Dr. William B. Kurtz is a board-certified, fellowship-trained orthopedic surgeon who specializes in hip and knee replacements at Tennessee Orthopaedic Alliance.
Dr. Kurtz holds a bachelor’s degree in mechanical engineering from Rice University. He graduated medical school from The University of Texas Southwestern Medical School at Dallas with Alpha Omega Alpha honors distinction. He completed a residency in orthopedic surgery at Vanderbilt University Medical Center, followed by a subspecialty fellowship in adult reconstructive joint surgery at New England Baptist Hospital in Boston.
Topics include:
-His role in Ortho Founders, a place where orthopreneurs can pitch their innovations and gain feedback from other leaders in orthopedics.
-Dr. Will Kurtz is President of Tennessee Orthopaedic Alliance, a group of 106 physicians. He is also a board member in Ortho Forum, whose members comprise 100 private practice groups across the U.S. to share data analysis and best practices on revenue cycle management and ancillary revenue streams.
-He’s done over 10,000 Conformis knees, made specifically for the patient. Dr. Kurtz breaks down the difference between Conformis personalized knees and a standard total knee, which comes off-the-shelf.
ZYNRELEF utilizes a novel synergistic mechanism of action that combines bupivacaine with a low dose of meloxicam to overcome the challenges of the inflammatory process at the surgical site. ZYNRELEF is the first and only extended-release dual-acting local anesthetic™ (DALA™) and delivers 72 hours of postoperative pain relief via a single needle-free application. It has been clinically proven to better manage pain than standard of care bupivacaine HCl solution over 72 hours and to significantly reduce opioid utilization following surgery.
-ZYNRELEF was initially approved by the FDA in May 2021 and in December 2021, the FDA approved an expansion of ZYNRELEF’s indication.
-Limitations of Use: Safety and efficacy have not been established in highly vascular surgeries, such as intrathoracic, large multilevel spinal, and head and neck procedures.
WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS
See full prescribing information for complete boxed warning.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use
• ZYNRELEF is contraindicated in the setting of coronary artery bypass graft (CABG) surgery
• NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events
ZYNRELEF is contraindicated for:
• Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF OR history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients
• Patients undergoing obstetrical paracervical block anesthesia OR coronary artery bypass graft (CABG) surgery
WARNINGS AND PRECAUTIONS include –
Cardiovascular (CV) Thrombotic Events with NSAID Use; Gastrointestinal Bleeding, Ulceration, and Perforation with NSAID Use; Dose-Related Toxicity; Risk of Use in Patients with Impaired Cardiovascular Function; Hepatotoxicity; Hypertension; Heart Failure and Edema; Renal Toxicity and Hyperkalemia; Anaphylactic Reactions; Chondrolysis; Methemoglobinemia; Exacerbation of Asthma Related to Aspirin Sensitivity; Serious Skin Reactions; Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); Hematologic Toxicity; Masking of Inflammation and Fever.
This episode is brought to you by TrackableMed, the place to go to help grow your new patient base.
Zed Williamson is the Founder/CEO of TrackableMed. After spending years in advertising, Zed Williamson founded TrackableMed in 2011, a patient demand acceleration program platform rooted in neuroscience. TrackableMed’s focus is on results and defined as booked patient appointments for specialty medical practices.
Topics include:
-Why did he create TrackableMed? He was a part of the advertising world and not fond of the industry. TrackableMed is built on results and defined as something you can deposit into a bank account.
-How does TrackableMed work? It’s a highly innovative business focused on the biases and heuristics of human behavior helping private practices create patient demand to their therapies. They attract potential patients by connective specifically with their pain.
-What you need to think about as a physician when setting up a meeting with TrackableMed? To start with:
-What is your goal?
-What is success to you?
-Who do you want to focus on from a patient profile to come through the door?
This episode is brought to you by Koha Health. At Koha Health, their goal is empowering your practice to achieve total financial health.
Dr. Jason Scopp is a sports medicine, orthopedic surgeon at Peninsula Orthopaedic Associates in Salisbury, MD. A lifelong athlete himself, Dr. Scopp has been team physician for the United States Soccer Team, University of Maryland Eastern Shore, Salisbury University, and the Delmarva Shorebirds (a Baltimore Orioles organization), among others. He’s a pioneer in the field of cartilage restoration, a procedure for joint pain available in only a handful of medical centers across the country. In addition to his biotechnology research on joint preservation, Dr. Scopp specializes in the treatment and prevention of sports-related injuries. He is an internationally featured speaker on the topics of joint preservation, cartilage defects and restorative treatment options.
Topics include:
-He has kindergarten drawings showing him wanting to be a doctor when he grew up. He wins on the show for the youngest age knowing when he’s wanted to be a doctor!
-Born and raised in Malibu and Santa Monica, he went to the east coast for schooling. He wanted to experience seasons outside of California to check out what it was like outside of 72 degrees and sunny. Dr. Scopp received his medical degree from the Hahnemann University School of Medicine in Philadelphia. His residency in orthopaedic surgery was completed at University of Maryland Medical Systems, and he completed his fellowship in sports medicine, arthroscopy, and articular cartilage restoration back on the west coast at the Santa Monica Orthopaedic and Sports Medicine Group in California. He is now on the opposite coast living near Ocean City, MD.
-Dr. Scopp offers sage advice for those in a private practice and being able to build a reputation as being a thought-leader in orthopedics.
This episode is brought to you by Koha Health. At Koha Health, their goal is empowering your practice to achieve total financial health.
Dr. David Flanigan is a sports medicine, orthopedic surgeon at The Ohio State University Wexner Medical Center. He is the Director of the Cartilage Restoration Program and is the Ohio State Department of Athletics Team Physician. When it comes to the knee, he’s your guy!
Topics include:
-Dr. Flanigan is a born and bred Midwesterner growing up outside of Chicago. He discusses growing up in a family with a hard work ethic and working towards the American dream, like his grandfather did as an immigrant from Sweden.
-We hear about his position as the Director of Ohio State Cartilage Restoration Program and what is new in cartilage now.
-Dr. Flanigan is a member of the Multi-center Orthopedic Outcomes Network (MOON) group. It’s an amazing large network of physicians and pioneers across the U.S. gathering information on ACL reconstruction.
-We also discuss the Moximed MISHA Knee System, which is an implantable shock absorber designed to unload the knee. Find out more about the knee system here.
This episode is brought to you by Koha Health. At Koha Health, their goal is empowering your practice to achieve total financial health.
Dr. Sara L. Edwards is an orthopedic surgeon who specializes in caring for patients with shoulder, elbow and knee injuries at UCSF Health. She provides surgical treatment for shoulder arthritis, including complex shoulder arthroplasty (reconstruction or replacement of the joint) and revisions. She also cares for patients of all ages with sports-related injuries. She treats athletes at all levels, from recreational to elite. Dr. Edwards is also a team doctor for City College of San Francisco, the University of San Francisco and the Oakland Ballet.
Topics include:
-It’s indeed a small world! Scott Sigman MD‘s father and her father were chemical engineer’s in Decatur, IL
-A traumatic car accident in senior year of high school influenced her in going into the medical field
-Being a part of the 6% of women in orthopedics
-At Northwestern University Feinberg School of Medicine, Edwards earned her medical degree and completed a residency in orthopedic surgery, serving as chief resident. She then completed a sports medicine fellowship in orthopedic surgery at Columbia University, where she served as the Charles S. Neer MD Shoulder and Elbow Fellow
-Family is important to Dr. Edwards and the reason she went into practice in a few locations across the U.S. We hear about how she went into private practice in Oakland for a few years, then returned to her alma mater as team physician for Northwestern University and how she made her way to UCSF.
Dr James Gladstone is the Chief of the Sports Medicine Service and Associate Professor of Orthopedic Surgery at the Icahn School of Medicine at Mount Sinai. He is the leading expert in the treatment of sports injuries, in particular, those of the knee and shoulder.
Topics include:
Both of his parents were U.S. citizens, yet he was born in Geneva, Switzerland. His father was an international diplomat and we hear about how he grew up in Switzerland, as well as the move back to the U.S. as an adult.
Dr. Gladstone graduated from Dartmouth College and Tufts University School of Medicine. He did his Orthopedic residency at the New York Orthopaedic Hospital of Columbia Presbyterian’s College of Physicians and Surgeons. He also completed a Sports Medicine fellowship at the American Sports Medicine Institute in Birmingham, Alabama under Drs. James Andrews and William Clancy. Following fellowship, he joined the Department of Orthopedic Surgery at Mount Sinai where he helped develop the Division of Sports Medicine and has stayed at the forefront of his field teaching medical students, residents, and fellows.
Topics include:
-He has a unique path in becoming a doctor, especially since he hated seeing blood as a child.
-How he started his practice in NYC as a small fish in the big sea. He hit the pavement and said it normally takes 5-7 years to build a practice. However, in NYC it normally takes 20 years to build your orthopedic practice and need grit to stick with it.
-Find out what’s exciting him in sports medicine now.
-We hear about what he would tell his young self about his future and where he’d be today.
This episode is brought to you by TrackableMed, the place to go to help grow your new patient base.
This episode is brought to you by Heron Therapeutics. Please see full Prescribing Information, including Boxed Warning or visit www.ZYNRELEF.com.
Dror Paley, MD, FRCSC, is the founder (2009) and director of the Paley Institute in West Palm Beach, Florida. Prior to that he was the founder (2001) and director of the Rubin Institute for Advanced Orthopedics, and the director of the International Center for Limb Lengthening (ICLL) at Sinai Hospital of Baltimore from 2001-2009. He was the Chief of Pediatric Orthopedics at the University of Maryland in Baltimore 1987-2001. He is internationally recognized for his expertise in limb lengthening and reconstruction.
Topics include:
-We hear why he went into orthopedics and then chose the niche path for limb lengthening. Dr. Paley trained under the guidance of Professor Ilizarov of Russia (Ilizarov method) and Professor Debastiani of Italy (Orthofix method). In 1986, he introduced the Ilizarov method to the United States and Canada. Since that time, he has performed more than 20,000 limb lengthening and reconstruction-related procedures. Patients come to his Institute from more than 100 countries.
-Dr. Paley reviews how limb lengthening works and breaks down this complex topic for anyone to understand, including the different types of limb lengthening to include the use of external fixators, often called cages, and remote controlled internal limb lengthening.
ZYNRELEF utilizes a novel synergistic mechanism of action that combines bupivacaine with a low dose of meloxicam to overcome the challenges of the inflammatory process at the surgical site. ZYNRELEF is the first and only extended-release dual-acting local anesthetic™ (DALA™) and delivers 72 hours of postoperative pain relief via a single needle-free application. It has been clinically proven to better manage pain than standard of care bupivacaine HCl solution over 72 hours and to significantly reduce opioid utilization following surgery.
-ZYNRELEF was initially approved by the FDA in May 2021 and in December 2021, the FDA approved an expansion of ZYNRELEF’s indication.
-Limitations of Use: Safety and efficacy have not been established in highly vascular surgeries, such as intrathoracic, large multilevel spinal, and head and neck procedures.
WARNING: RISK OF SERIOUS CARDIOVASCULAR AND GASTROINTESTINAL EVENTS
See full prescribing information for complete boxed warning.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use
• ZYNRELEF is contraindicated in the setting of coronary artery bypass graft (CABG) surgery
• NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events
ZYNRELEF is contraindicated for:
• Patients with a known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to any local anesthetic agent of the amide-type, NSAIDs, or to any of the other components of ZYNRELEF OR history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients
• Patients undergoing obstetrical paracervical block anesthesia OR coronary artery bypass graft (CABG) surgery
WARNINGS AND PRECAUTIONS include –
Cardiovascular (CV) Thrombotic Events with NSAID Use; Gastrointestinal Bleeding, Ulceration, and Perforation with NSAID Use; Dose-Related Toxicity; Risk of Use in Patients with Impaired Cardiovascular Function; Hepatotoxicity; Hypertension; Heart Failure and Edema; Renal Toxicity and Hyperkalemia; Anaphylactic Reactions; Chondrolysis; Methemoglobinemia; Exacerbation of Asthma Related to Aspirin Sensitivity; Serious Skin Reactions; Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS); Hematologic Toxicity; Masking of Inflammation and Fever.
